Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria
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چکیده
منابع مشابه
IRGM in autophagy and viral infections
Autophagy is a cell autonomous process allowing each individual cell to fight intracellular pathogens. Autophagy can destroy pathogens within the cytosol, and can elicit innate and adaptive immune responses against microorganisms. Nevertheless, numerous pathogens have developed molecular strategies enabling them to avoid or even exploit autophagy for their own benefit. IRGM (immunity-related GT...
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Mitochondria form close physical associations with the endoplasmic reticulum (ER) that regulate a number of physiological functions. One mechanism by which regions of ER are recruited to mitochondria involves binding of the ER protein VAPB to the mitochondrial protein PTPIP51, which act as scaffolds to tether the two organelles. Here, we show that the VAPB-PTPIP51 tethers regulate autophagy. We...
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ژورنال
عنوان ژورنال: Nature Cell Biology
سال: 2010
ISSN: 1465-7392,1476-4679
DOI: 10.1038/ncb2119